LA VARIABILITA’ PRESSORIA A BREVE TERMINE NON E’ASSOCIATA ALLA DISFUNZIONE RENALE LIEVENELL'IPERTENSIONE ARTERIOSA PRIMARIA

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Abstract

[automatically translated] RATIONAL. The prognostic significance of short-term variability in blood pressure (VP), expressed as standard deviation (SD), it is controversial. Have recently been proposed in the short term other VP indexes, including the Average Real Variability (ARV), it seems to be more associated to cardiovascular risk (CV). It not investigated, so far is the relationship between ARV and mild renal dysfunction. The aim of our study was to analyze the relationships of 'ARV of 24 h and other VP indexes in the short term with the' albuminuria (AER) and the glomerular filtration rate (eGFR) in a group of essential hypertension, untreated. CASES AND METHODS. They enrolled 248 patients (mean age 48 ± 14 years, 44% women), with essential hypertension and with eGFR> 60 ml / min / 1.73 m2. Of them 73 were considered to have mild renal dysfunction (DRL), in relation to membership in the first two stages of CKD, according to KDIGO guidelines of 2012. RESULTS. None of the short-term VP indices studied [ARV of arterial pressure (PA) of 24 h, SD weighted the PA of 24 h, SD of the PA of the day or night] are different results in those with DRL, compared with hypertensive normal renal function. Weak correlations were observed between ARV logarithm of systolic BP and the logarithm of 'AER (r = 0.130; p = 0.04) and between the first and eGFR (- 0.131; p = 0.04). These correlations have lost statistical significance in multiple linear regression models, after adjusting for potential confounders. Similarly, the analysis of multiple logistic regression, none of the short-term VP indices examined, was associated independently to DRL. CONCLUSIONS. Our results suggest that essential nell'iperteso none of the short-term VP indexes, obtainable via the PA batch monitoring of 24 hours, is associated with DRL.
Original languageItalian
Pages176-176
Number of pages1
Publication statusPublished - 2014

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