Abstract

[automatically translated] Hypertension is an increasingly common cause of end-stage kidney failure; is also well known as the presence of kidney dysfunction, however slight, leads to a significant increase in cardiovascular risk. Recently it assessed the prevalence of renal dysfunction in hypertensive patients without cardiovascular complications or known renal disease, study participants Renal Dysfunction in Hypertension (REDHY), using four methods of estimating glomerular filtration rate (GFR): creatinine clearance (CrCl) , the simplified equation of the Modification of Diet in Renal Disease study (MDRD), the Cockcroft-Gault formula (CG) and the equation of the Mayo Clinic (Mayo). The prevalence of albuminuria was 23.4% (22.7% microalbuminuria, macroalbuminuria 0.7%). A mild renal dysfunction (AER> 20 g / min and GFR> 60 ml / min per 1.73 m2) was highlighted by 20.3% (CrCl) to 18.4% (MDRD) of the patients. The prevalence of 'overt renal insufficiency (GFR <60 ml / min per 1.73 m2) was higher using creatinine clearance (10.8%) or the MDRD equation (10%) compared to the CG formula (7.4 %) or equation Mayo (5.4%) (p <0.0001). Renal dysfunction can therefore be considered very frequent in hypertensive subjects without cardiovascular complications, while taking into account the prevalence of moderate to severe impairment of renal function is strongly influenced by the methods used to estimate glomerular filtration rate. The prevalence of 'overt renal insufficiency (GFR <60 ml / min per 1.73 m2) was higher using creatinine clearance (10.8%) or the MDRD equation (10%) compared to the CG formula (7.4 %) or equation Mayo (5.4%) (p <0.0001). Renal dysfunction can therefore be considered very frequent in hypertensive subjects without cardiovascular complications, while taking into account the prevalence of moderate to severe impairment of renal function is strongly influenced by the methods used to estimate glomerular filtration rate. The prevalence of 'overt renal insufficiency (GFR <60 ml / min per 1.73 m2) was higher using creatinine clearance (10.8%) or the MDRD equation (10%) compared to the CG formula (7.4 %) or equation Mayo (5.4%) (p <0.0001). Renal dysfunction can therefore be considered very frequent in hypertensive subjects without cardiovascular complications, while taking into account the prevalence of moderate to severe impairment of renal function is strongly influenced by the methods used to estimate glomerular filtration rate.
Original languageItalian
Pages (from-to)24-29
Number of pages6
JournalGIORNALE ITALIANO DI CARDIOLOGIA PRATICA
Volume2009
Publication statusPublished - 2009

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