Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.

Giuseppe Di Giovanni; Giuseppe Crescimanno; Arcangelo Benigno; Ennio Esposito; Massimo Pierucci; Vincenzo Di Matteo

Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.

Giuseppe Di Giovanni, Giuseppe Crescimanno, Arcangelo Benigno, Ennio Esposito, Massimo Pierucci, Vincenzo Di Matteo

Biomedicina, Neuroscienze e Diagnostica avanzata

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.

Original language	English
Pages (from-to)	309-315
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1155
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

Fingerprint Dive into the research topics of 'Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.'. Together they form a unique fingerprint.

Cite this

Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study. / Di Giovanni, Giuseppe ; Crescimanno, Giuseppe ; Benigno, Arcangelo; Esposito, Ennio; Pierucci, Massimo; Di Matteo, Vincenzo.

In: Annals of the New York Academy of Sciences, Vol. 1155, 2009, p. 309-315.

Research output: Contribution to journal › Article › peer-review

@article{fca2b68e3f6b472793a1830587edd39d,

title = "Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.",

abstract = "The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.",

author = "{Di Giovanni}, Giuseppe and Giuseppe Crescimanno and Arcangelo Benigno and Ennio Esposito and Massimo Pierucci and {Di Matteo}, Vincenzo",

year = "2009",

language = "English",

volume = "1155",

pages = "309--315",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.

AU - Di Giovanni, Giuseppe

AU - Crescimanno, Giuseppe

AU - Benigno, Arcangelo

AU - Esposito, Ennio

AU - Pierucci, Massimo

AU - Di Matteo, Vincenzo

PY - 2009

Y1 - 2009

N2 - The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.

AB - The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n= 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, n= 5), an NO donor, significantly worsened the neurodegeneration (n= 5) and completely counteracted the neuroprotective effect of 7-NI (n= 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.

UR - http://hdl.handle.net/10447/51686

M3 - Article

VL - 1155

SP - 309

EP - 315

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -

Involvement of Nitric Oxide in Nigrostriatal Dopaminergic System Degeneration : A Neurochemical Study.

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Cite this