Introduction: Alterations of the renal microcirculationhave been documented in animal models of hypertensiverenal damage. Traditionally, the retina has been consideredthe easiest accessible window to study the systemicmicrocirculation, even though the choroid is the mostimportant vascular layer of the eye. The introduction in thepast few years of advanced optical coherence tomography(OCT) techniques has greatly increased our understandingof the choroid. Although the renal resistive index (RRI)was initially considered to reflect intrarenal vascularpathological processes, this index is actually regarded asthe result of complex interaction between renal and systemicvascular wall properties and hemodynamic factors,and it is endowed with prognostic implications.Aim: To analyse the relationships between choroidalthickness (CT) and RRI in a group of hypertensive patients.Methods: We enrolled 66 nondiabetic essential hypertensives(67% men; mean age: 52 ± 12 years), consecutivelyattending our Hypertension Centre.Results: The glomerular filtration rate (GFR) estimated bythe CKD-EPI equation was 78 ± 2 ml/min/1.73 m2, andthe RRI 0.64 ± 0.07. Splitting the study population into 2groups on the basis of the 75th percentile of the distributionof RRI, we found lower choroidal thickness in the groupwith greater values of RRI (all p.001; Figure 3). Weobserved also significant inverse correlations between CTand RRI, that held even after adjustment for GFR, age andgender (Table 3).Conclusions: Our findings confirm the close relationshipsbetween changes in the ocular microcirculation and renaldysfunction and suggest that intrarenal hemodynamicalterations are involved in these relationships.
|Number of pages||2|
|Journal||HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION|
|Publication status||Published - 2019|
Cottone, S., Vadala', M., Geraci, G., Mule', G., D'Ignoto, F., & Sinatra, N. (2019). INVERSE RELATIONSHIPS BETWEENCHOROIDAL THICKNESS AND RENALRESISTANCE INDEX IN HYPERTENSIVEPATIENTS. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 26, 167-168.