INVERSE RELATIONSHIP BETWEEN CHOROIDAL THICKNESS AND SUBCLINICAL RENAL DAMAGE IN ESSENTIAL HYPERTENSION

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Abstract

The introduction in last years of advanced techniques of optical coherencetomography (OCT) has greatly increased our understanding of the choroid, that isthe most important vascular layer of the eye. Our study was aimed to assesschoroidal thickness by using Swept-Source OCT (SS-OCT) in essential hypertensivepatients (EHs) with and without subclinical renal damage (SRD).We enrolled 100 EHs of which 65 without kidney damage and 35 with SRD. In all theparticipants SS-OCT and a routine biochemical workup were performed. Glomerularfiltration rate (GFR) was estimated by the CKD-EPI equation (eGFR). SRD wasdefined, by the presence of microalbuminuria or eGFR between 30 and 60mL/min/1.73 m2. OCT measurements were performed according to the EarlyTreatment Diabetic Retinopathy Study (ETDRS) protocol, that divides the macula into9 subfields. The circular grid consists of 3 concentric rings.EHs with SRD showed thinner choroidal thicknesses than those without kidneydamage (all p < 0.05), even after adjustment for age. Overall choroidal thicknesscorrelated significantly and directly with eGFR (r = 0.36) and negatively with urinaryalbumin excretion (r = – 0.39). The association of choroidal thickness with SRD wasconfirmed in multiple logistic regression analyses once the effect of age, antihypertensivetherapy and triglycerides was accounted for. The odds ratio of havingSRD associated with a standard deviation increase of overall choroidal thickness was0.43 (0.24–0.75, 95% confidence interval; p = 0.007).In conclusion, our study confirms the close relationships between changes in ocularmicrocirculation and renal dysfunction.
Original languageEnglish
Number of pages1
Publication statusPublished - 2018

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