Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome

Giuliana Guggino, Guido Sireci, Francesco Ciccia, Francesco Ciccia, Chiara Rizzo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.
Original languageEnglish
Pages (from-to)5435-
Number of pages13
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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