Inulin coated plasmonic gold nanoparticles as a tumor-selective tool for cancer therapy

Mariano Licciardi, Gaetano Giammona, Anna Li Volsi, Mariano Licciardi, Malou Henriksen-Lacey, Dorleta Jimenez De Aberasturi, Luis M. Liz-Marzán, Gaetano Giammona

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Polymer coated gold nanospheres are proposed as a tumor selective carrier for the anticancer drug doxorubicin. Thiolated polyethyleneglycol (PEG-SH) and an inulin-amino derivative based copolymer (INU-EDA) were used as stabilizing and coating materials for 40 nm gold nanospheres. The resulting polymer coated gold nanospheres (Au@PEG-INU) showed excellent physicochemical stability and potential stealth like behavior. The system was loaded with doxorubicin (Au@PEG-INU/Doxo) and its cytotoxicity profile was evaluated on human cervical cancer cells (HeLa) and lung cancer cells (A549), as compared to Au@PEG-INU and doxorubicin alone. Cytotoxicity assays showed that the system is able to drastically reduce cell viability upon incubation for 3 days. This result was supported by the ability of Au@PEG-INU/Doxo to be internalized by cancer cells and to release doxorubicin, as assessed by fluorescence microscopy. Finally, a cancer/non cancer cell co-culture model was used to display the advantageous therapeutic effects of the proposed system with respect to doxorubicin alone, thereby demonstrating the ability of Au@PEG-INU/Doxo to preferentially accumulate in tumor cells due to their enhanced metabolism, and to selectively kill target cells.
Original languageEnglish
Pages (from-to)1150-1155
Number of pages6
JournalJOURNAL OF MATERIALS CHEMISTRY. B
Volume4
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science

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