Intraoperative parathyroid hormone monitoring during parathyroidectomy for hyperparathyroidism in waiting list and kidney transplant patients

Maria Concetta Gioviale, Maurizio Romano, Attilio Ignazio Lo Monte, Emerico Luna, Giuseppe Buscemi, Alessandro Di Bona, Fiorella Calderone, Giovanni Gambino

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18 Citations (Scopus)

Abstract

This report describes the use of the intraoperative parathyroid hormone (ioPTH) assay during parathyroidectomy in waiting list and transplanted patients. ioPTH levels were determined in 40 patients on the waiting list for kidney transplantation with secondary hyperparathyroidism who underwent subtotal parathyroidectomy and 9 transplanted patients with tertiary hyperparathyroidism who underwent removal of hyperplasic glands. Rapid PTH levels decreased significantly at each time period; the percentage decrease in rapid PTH levels was 61.3% among patients with IPT II and 70.2% in patients with IPT III at 10 minutes and 86.5% in patients with IPT II and 91% in patients with IPT III at 15 minutes after excision of hypersecreting parathyroid tissue. A decrease of 50% or more from baseline PTH levels at 10 minutes and/or a decrease of 85% or more at 15 minutes predicted successful removal of abnormal parathyroid glands. The application of this technique during subtotal parathyroidectomy has proved useful for correct excision of parathyroid glands among waiting list patients with IPT II, while in kidney transplant patients with IPT III it allowed removal of only the pathological glands with a limited surgical approach.
Original languageEnglish
Pages (from-to)1003-1005
Number of pages3
JournalTransplantation Proceedings
Volume38
Publication statusPublished - 2006

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Parathyroidectomy
Waiting Lists
Hyperparathyroidism
Parathyroid Hormone
Transplants
Kidney
Parathyroid Glands
Secondary Hyperparathyroidism
Kidney Transplantation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

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title = "Intraoperative parathyroid hormone monitoring during parathyroidectomy for hyperparathyroidism in waiting list and kidney transplant patients",
abstract = "This report describes the use of the intraoperative parathyroid hormone (ioPTH) assay during parathyroidectomy in waiting list and transplanted patients. ioPTH levels were determined in 40 patients on the waiting list for kidney transplantation with secondary hyperparathyroidism who underwent subtotal parathyroidectomy and 9 transplanted patients with tertiary hyperparathyroidism who underwent removal of hyperplasic glands. Rapid PTH levels decreased significantly at each time period; the percentage decrease in rapid PTH levels was 61.3{\%} among patients with IPT II and 70.2{\%} in patients with IPT III at 10 minutes and 86.5{\%} in patients with IPT II and 91{\%} in patients with IPT III at 15 minutes after excision of hypersecreting parathyroid tissue. A decrease of 50{\%} or more from baseline PTH levels at 10 minutes and/or a decrease of 85{\%} or more at 15 minutes predicted successful removal of abnormal parathyroid glands. The application of this technique during subtotal parathyroidectomy has proved useful for correct excision of parathyroid glands among waiting list patients with IPT II, while in kidney transplant patients with IPT III it allowed removal of only the pathological glands with a limited surgical approach.",
author = "Gioviale, {Maria Concetta} and Maurizio Romano and {Lo Monte}, {Attilio Ignazio} and Emerico Luna and Giuseppe Buscemi and {Di Bona}, Alessandro and Fiorella Calderone and Giovanni Gambino",
year = "2006",
language = "English",
volume = "38",
pages = "1003--1005",
journal = "Transplantation Proceedings",
issn = "0041-1345",
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TY - JOUR

T1 - Intraoperative parathyroid hormone monitoring during parathyroidectomy for hyperparathyroidism in waiting list and kidney transplant patients

AU - Gioviale, Maria Concetta

AU - Romano, Maurizio

AU - Lo Monte, Attilio Ignazio

AU - Luna, Emerico

AU - Buscemi, Giuseppe

AU - Di Bona, Alessandro

AU - Calderone, Fiorella

AU - Gambino, Giovanni

PY - 2006

Y1 - 2006

N2 - This report describes the use of the intraoperative parathyroid hormone (ioPTH) assay during parathyroidectomy in waiting list and transplanted patients. ioPTH levels were determined in 40 patients on the waiting list for kidney transplantation with secondary hyperparathyroidism who underwent subtotal parathyroidectomy and 9 transplanted patients with tertiary hyperparathyroidism who underwent removal of hyperplasic glands. Rapid PTH levels decreased significantly at each time period; the percentage decrease in rapid PTH levels was 61.3% among patients with IPT II and 70.2% in patients with IPT III at 10 minutes and 86.5% in patients with IPT II and 91% in patients with IPT III at 15 minutes after excision of hypersecreting parathyroid tissue. A decrease of 50% or more from baseline PTH levels at 10 minutes and/or a decrease of 85% or more at 15 minutes predicted successful removal of abnormal parathyroid glands. The application of this technique during subtotal parathyroidectomy has proved useful for correct excision of parathyroid glands among waiting list patients with IPT II, while in kidney transplant patients with IPT III it allowed removal of only the pathological glands with a limited surgical approach.

AB - This report describes the use of the intraoperative parathyroid hormone (ioPTH) assay during parathyroidectomy in waiting list and transplanted patients. ioPTH levels were determined in 40 patients on the waiting list for kidney transplantation with secondary hyperparathyroidism who underwent subtotal parathyroidectomy and 9 transplanted patients with tertiary hyperparathyroidism who underwent removal of hyperplasic glands. Rapid PTH levels decreased significantly at each time period; the percentage decrease in rapid PTH levels was 61.3% among patients with IPT II and 70.2% in patients with IPT III at 10 minutes and 86.5% in patients with IPT II and 91% in patients with IPT III at 15 minutes after excision of hypersecreting parathyroid tissue. A decrease of 50% or more from baseline PTH levels at 10 minutes and/or a decrease of 85% or more at 15 minutes predicted successful removal of abnormal parathyroid glands. The application of this technique during subtotal parathyroidectomy has proved useful for correct excision of parathyroid glands among waiting list patients with IPT II, while in kidney transplant patients with IPT III it allowed removal of only the pathological glands with a limited surgical approach.

UR - http://hdl.handle.net/10447/10388

M3 - Article

VL - 38

SP - 1003

EP - 1005

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

ER -