Interaction of alcohol intake and cofactors on the risk of cirrhosis.

Pier Luigi Almasio, Lorenzo A. Surace, Carmela Loguercio, Stefano Bellentani, Tommaso Stroffolini, Enzo Petrelli, Maria T. Salerno, Gaetano Cotticelli, Emanuela Medda, Antonio Picardi, Piero Almasio, Giovanni Addolorato, Camillo Del Vecchio-Blanco, Maria T. Salerno, Mauro Bernardi, Marco Niosi

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36 Citations (Scopus)


OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females (OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more than 2 cups/day.CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.
Original languageEnglish
Number of pages4
JournalLiver International
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Hepatology

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