Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

Paola Barraja, Anna Carbone, Alessandra Montalbano, Maria Valeria Raimondi, Antonio Palumbo Piccionello, Marilia Barreca, Virginia Spano', Ernest Hamel, Roberta Bortolozzi, Roberta Rocca, Stefano Alcaro, Giampietro Viola, Ruoli Bai

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative activity of the new compounds on the full NCI human tumor cell line panel highlighted several compounds that are able to inhibit tumor cell proliferation at micromolar-submicromolar concentrations. The most active derivative 11g was found to cause cell cycle arrest at the G2/M phase and induce apoptosis in HeLa cells, following the mitochondrial pathway, making it a lead compound for the discovery of new antimitotic drugs.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalEuropean Journal of Medicinal Chemistry
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors'. Together they form a unique fingerprint.

Cite this