Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients.

Massimo Midiri, Calogera Gerardi, Alessia Pepe, Luigi Landini, Carmela Lo Pinto, Antonella Meloni, Vincenzo Positano, Marcello Capra, Maria Filomena Santarelli, Aurelio Maggio, Massimo Lombardi, Brunella Favilli

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24 Citations (Scopus)


PURPOSE: To determine whether T2* measurements quantifying myocardial iron overload in thalassemia patients are influenced by myocardial fibrosis and blood oxygenation. MATERIALS AND METHODS: Multislice multiecho T2* was performed in 94 thalassemia patients in order to quantify myocardial iron overload. The left ventricle was automatically segmented into a 16-segment standardized heart model, and the T2* value on each segment as well as the global T2* were calculated. Delayed enhanced cardiovascular magnetic resonance (DE-CMR) images were obtained to detect myocardial fibrosis. The blood oxygenation was assessed by the noninvasive measurement of partial pressure of oxygen (pO2). RESULTS: Myocardial fibrosis was detected in 31 patients (33%). The global T2* value in patients with fibrosis was comparable with that of patients without fibrosis (P = 0.88) and T2* values in segments with fibrosis were comparable with those in segments without fibrosis (P = 0.83). The global T2* value was not correlated with the pO2 (Spearman's coefficient of correlation = 0.99). CONCLUSION: Myocardial fibrosis and blood oxygenation did not significantly affect the T2* values. These data further support the use of heart T2* as equivalent of heart iron in the clinical arena.
Original languageEnglish
Pages (from-to)832-837
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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