Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans

Maria Antonietta Sabatino, Simona Todaro, Clelia Dispenza, Marta Walo, Dispenza, Todaro, Maria Rosalia Mangione, Bulone

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to the irreversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucansinteresting raw materials also in the form of micro/nanoparticles for application as nanoscalar drugdelivery devices in cosmetic and pharmaceutical formulations.Owing to their natural source,xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiatedxyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. Theaggregation kinetics at 37°C were studied by dynamic light scattering measurements toconfirm the temperature-responsive behavior of this polymer even when dispersed in water at lowconcentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.
Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalRadiation Physics and Chemistry
Volume94
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Radiation

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