Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project

Roberto Monastero; null Guizzardi; null Cascavilla; null Gallucci; null Costanzi; null Cester; null Mossello; null Chiaranti; null Formilan; null Codemo; null Renna; null Sica; null Spaccamento; null Vitrano Catania; Francesca Fortunato; null Marinelli; null Masiello; null Estraneo; null Carbonin; null Del Prete; null Gandolfi; null Cucinotta; null Tripi; null Ferrari; null Bartorelli; null Ricci; null Ferrari; null Dallari; null Scognamiglio; null Marinelli; null Sacco; null Giordano; null Reggiani; Angelo Di Iorio; null Biagini; null Cavallini; null Di Palma; null Ferrari; null Cerqua; null Tripi; null Reggiani; null Tripi; null Busonera; null Pippi; null Putzu; null Anzivino; null Cerqua; null Frazzitta; null Cuzzoni; null Ercolani; null Mussi; null Del Re; null Canonico; Carlo Gabelli; null Bavazzano; null Zanetti; Vittorio Nicita-Mauro; null Senin; null Capurso; null Silveri; null Mecocci; Roberto Casale; null Vitale; Patrizio Odetti; null Enzi; null Pilotto; Giulio Masotti; null Rinaldi; Giorgio Basile; null Mariani; null Bernabei; null Salvioli; null Abate; Franco Rengo; null Cataldi; null Ferrari; null Ferrari; null Ascari; null Mangialasche; null Marchetti; null Ellena; Domenico Vitale

Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project

Roberto Monastero, Guizzardi, Cascavilla, Gallucci, Costanzi, Cester, Mossello, Chiaranti, Formilan, Codemo, Renna, Sica, Spaccamento, Vitrano Catania, Francesca Fortunato, Marinelli, Masiello, Estraneo, Carbonin, Del PreteGandolfi, Cucinotta, Tripi, Ferrari, Bartorelli, Ricci, Ferrari, Dallari, Scognamiglio, Marinelli, Sacco, Giordano, Reggiani, Angelo Di Iorio, Biagini, Cavallini, Di Palma, Ferrari, Cerqua, Tripi, Reggiani, Tripi, Busonera, Pippi, Putzu, Anzivino, Cerqua, Frazzitta, Cuzzoni, Ercolani, Mussi, Del Re, Canonico, Carlo Gabelli, Bavazzano, Zanetti, Vittorio Nicita-Mauro, Senin, Capurso, Silveri, Mecocci, Roberto Casale, Vitale, Patrizio Odetti, Enzi, Pilotto, Giulio Masotti, Rinaldi, Giorgio Basile, Mariani, Bernabei, Salvioli, Abate, Franco Rengo, Cataldi, Ferrari, Ferrari, Ascari, Mangialasche, Marchetti, Ellena, Domenico Vitale

Biomedicina, Neuroscienze e Diagnostica avanzata

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVES:To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects.METHODS:The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cognition.RESULTS:Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes.CONCLUSION:In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL.

Original language	English
Pages (from-to)	523-530
Number of pages	8
Journal	International Journal of Geriatric Psychiatry
Volume	23
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Geriatrics and Gerontology
Psychiatry and Mental health

Cite this

Monastero, R., Guizzardi, Cascavilla, Gallucci, Costanzi, Cester, Mossello, Chiaranti, Formilan, Codemo, Renna, Sica, Spaccamento, Vitrano Catania, Fortunato, F., Marinelli, Masiello, Estraneo, Carbonin, ... Vitale, D. (2008). Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project. International Journal of Geriatric Psychiatry, 23, 523-530.

Monastero, R, Guizzardi, Cascavilla, Gallucci, Costanzi, Cester, Mossello, Chiaranti, Formilan, Codemo, Renna, Sica, Spaccamento, Vitrano Catania, Fortunato, F, Marinelli, Masiello, Estraneo, Carbonin, Del Prete, Gandolfi, Cucinotta, Tripi, Ferrari, Bartorelli, Ricci, Ferrari, Dallari, Scognamiglio, Marinelli, Sacco, Giordano, Reggiani, Di Iorio, A, Biagini, Cavallini, Di Palma, Ferrari, Cerqua, Tripi, Reggiani, Tripi, Busonera, Pippi, Putzu, Anzivino, Cerqua, Frazzitta, Cuzzoni, Ercolani, Mussi, Del Re, Canonico, Gabelli, C, Bavazzano, Zanetti, Nicita-Mauro, V, Senin, Capurso, Silveri, Mecocci, Casale, R, Vitale, Odetti, P, Enzi, Pilotto, Masotti, G, Rinaldi, Basile, G, Mariani, Bernabei, Salvioli, Abate, Rengo, F, Cataldi, Ferrari, Ferrari, Ascari, Mangialasche, Marchetti, Ellena & Vitale, D 2008, 'Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project', International Journal of Geriatric Psychiatry, vol. 23, pp. 523-530.

@article{525d0c2ddd0c44529b5a8ce6e1c56360,

title = "Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project",

abstract = "OBJECTIVES:To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects.METHODS:The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cognition.RESULTS:Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes.CONCLUSION:In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL.",

author = "Roberto Monastero and Guizzardi and Cascavilla and Gallucci and Costanzi and Cester and Mossello and Chiaranti and Formilan and Codemo and Renna and Sica and Spaccamento and {Vitrano Catania} and Francesca Fortunato and Marinelli and Masiello and Estraneo and Carbonin and {Del Prete} and Gandolfi and Cucinotta and Tripi and Ferrari and Bartorelli and Ricci and Ferrari and Dallari and Scognamiglio and Marinelli and Sacco and Giordano and Reggiani and {Di Iorio}, Angelo and Biagini and Cavallini and {Di Palma} and Ferrari and Cerqua and Tripi and Reggiani and Tripi and Busonera and Pippi and Putzu and Anzivino and Cerqua and Frazzitta and Cuzzoni and Ercolani and Mussi and {Del Re} and Canonico and Carlo Gabelli and Bavazzano and Zanetti and Vittorio Nicita-Mauro and Senin and Capurso and Silveri and Mecocci and Roberto Casale and Vitale and Patrizio Odetti and Enzi and Pilotto and Giulio Masotti and Rinaldi and Giorgio Basile and Mariani and Bernabei and Salvioli and Abate and Franco Rengo and Cataldi and Ferrari and Ferrari and Ascari and Mangialasche and Marchetti and Ellena and Domenico Vitale",

year = "2008",

language = "English",

volume = "23",

pages = "523--530",

journal = "International Journal of Geriatric Psychiatry",

issn = "0885-6230",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project

AU - Monastero, Roberto

AU - Guizzardi, null

AU - Cascavilla, null

AU - Gallucci, null

AU - Costanzi, null

AU - Cester, null

AU - Mossello, null

AU - Chiaranti, null

AU - Formilan, null

AU - Codemo, null

AU - Renna, null

AU - Sica, null

AU - Spaccamento, null

AU - Vitrano Catania, null

AU - Fortunato, Francesca

AU - Marinelli, null

AU - Masiello, null

AU - Estraneo, null

AU - Carbonin, null

AU - Del Prete, null

AU - Gandolfi, null

AU - Cucinotta, null

AU - Tripi, null

AU - Ferrari, null

AU - Bartorelli, null

AU - Ricci, null

AU - Ferrari, null

AU - Dallari, null

AU - Scognamiglio, null

AU - Marinelli, null

AU - Sacco, null

AU - Giordano, null

AU - Reggiani, null

AU - Di Iorio, Angelo

AU - Biagini, null

AU - Cavallini, null

AU - Di Palma, null

AU - Ferrari, null

AU - Cerqua, null

AU - Tripi, null

AU - Reggiani, null

AU - Tripi, null

AU - Busonera, null

AU - Pippi, null

AU - Putzu, null

AU - Anzivino, null

AU - Cerqua, null

AU - Frazzitta, null

AU - Cuzzoni, null

AU - Ercolani, null

AU - Mussi, null

AU - Del Re, null

AU - Canonico, null

AU - Gabelli, Carlo

AU - Bavazzano, null

AU - Zanetti, null

AU - Nicita-Mauro, Vittorio

AU - Senin, null

AU - Capurso, null

AU - Silveri, null

AU - Mecocci, null

AU - Casale, Roberto

AU - Vitale, null

AU - Odetti, Patrizio

AU - Enzi, null

AU - Pilotto, null

AU - Masotti, Giulio

AU - Rinaldi, null

AU - Basile, Giorgio

AU - Mariani, null

AU - Bernabei, null

AU - Salvioli, null

AU - Abate, null

AU - Rengo, Franco

AU - Cataldi, null

AU - Ferrari, null

AU - Ascari, null

AU - Mangialasche, null

AU - Marchetti, null

AU - Ellena, null

AU - Vitale, Domenico

PY - 2008

Y1 - 2008

N2 - OBJECTIVES:To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects.METHODS:The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cognition.RESULTS:Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes.CONCLUSION:In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL.

AB - OBJECTIVES:To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects.METHODS:The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cognition.RESULTS:Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes.CONCLUSION:In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL.

UR - http://hdl.handle.net/10447/25804

M3 - Article

SN - 0885-6230

VL - 23

SP - 523

EP - 530

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

ER -

Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project

Abstract

All Science Journal Classification (ASJC) codes

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