Inflammatory polyradiculoneuropathies: Clinical and immunological aspects, current therapies, and future perspectives

Vincenzo Di Stefano, Vincenzo Di Stefano, Michela Vitale, Camilla Ferrante, Filomena Barbone, Roberta Telese, Antonio Di Muzio, Marco Onofrj

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory polyradiculoneuropathies are heterogeneous disorders characterized by immune-mediated leukocyte infiltration of peripheral nerves and nerve roots leading to demyelination or axonal degeneration or both. Inflammatory polyradiculoneuropathies can be divided into acute and chronic: Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy and their variants. Despite major advances in immunology and molecular biology have been made in the last years, the pathogenesis of these disorders is not completely understood. This review summarizes the current literature of the clinical features and pathogenic mechanisms of inflammatory polyradiculoneuropathies and focuses on current therapies and new potential treatment for the future.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalEuropean Journal of Inflammation
Volume18
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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