Angelo Leone, Giovanni Tomasello, Francesca Rappa, Francesco Carini, Rosalyn Jurjus, Provvidenza Damiani, Tarek Bou Assi, Francesca Rappa, Alice Gerges Geagea, Eleonora Trovato, Giovanni Tomasello, Tarek Bou Assi, Tarek Bou Assi, Tarek Bou Assi, Abdo Jurjus

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Nutraceuticals constitute a group of functional foods that provide added health benefits for various disorders including inflammatory bowel disease (IBD) and colorectal cancer (CCR). The main groups of nutraceuticals include probiotics, prebiotics omega 3 and antioxidants. Studies on nutraceutical showed that this type of food possessed similar properties to drugs but with the benefit of not having side effects. This mini review shows that probiotics and prebiotics, when administered simultaneously with traditional therapies, reduce IBD symptoms and reduce synthesis of enzymes probably involved in colorectal carcinogenesis. Moreover, Omega 3 reduces the synthesis of inflammation mediators and prevenents carcinogenesis through interaction interaction with the signaling pathway NOTCH1/MMP9. Moreover, antioxidant reduce the inflammatory process by inhibiting the synthesis of inflammatory mediators, and inhibit the mechanisms of cell proliferation by inducing apoptosis. In brief, nutraceuticals have gained a huge clinical interest since they could be used along with traditional therapy. Bioavailability studies of nutracetical supplements guarantee a correct intake of the substance by oral administration, a matter which would not have been posible to have entirely with the consumprtion of regular food only.
Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalEuroMediterranean Biomedical Journal
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • General Medicine


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