Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease

Giulio Geraci, Antonio Pinto, Santina Cottone, Giuseppe Mule', Pietro Castellino, Daniele Torres, Antonio Pinto, Alessandra F. Perna, Kadir Ozturk, Musa B. Aykan, Gaia Riguccio, Andrea Duminuco, Gaetano Inserra, Antonio Tuttolomondo, Pasquale Fatuzzo, Pierre Boutouyrie, Stephane Laurent, Maria Cappello, Luca Zanoli, Daniele TorresGaetano Inserra

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Inflammatory bowel disease ( IBD ) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse-wave velocity ( aPWV ), and an excess of cardiovascular events. We have previously hypothesized that the cardiovascular risk excess reported in these patients could be explained by chronic inflammation. Here, we tested the hypothesis that chronic inflammation is responsible for the increased aPWV previously reported in IBD patients and that anti-TNFa (anti-tumor necrosis factor-alpha) therapy reduce aPWV in these patients. Methods and Results This was a multicenter longitudinal study. We enrolled 334 patients: 82 patients with ulcerative colitis, 85 patients with Crohn disease, and 167 healthy control subjects matched for age, sex, and mean blood pressure, from 3 centers in Europe, and followed them for 4 years (range, 2.5-5.7 years). At baseline, IBD patients had higher aPWV than controls. IBD patients in remission and those treated with anti-TNFa during follow-up experienced an aortic destiffening, whereas aPWV increased in those with active disease and those treated with salicylates ( P=0.01). Disease duration ( P=0.02) was associated with aortic stiffening as was, in patients with ulcerative colitis, high-sensitivity C-reactive protein during follow-up ( P=0.02). All these results were confirmed after adjustment for major confounders. Finally, the duration of anti-TNFa therapy was not associated with the magnitude of the reduction in aPWV at the end of follow-up ( P=0.85). Conclusions Long-term anti-TNFa therapy reduces aPWV , an established surrogate measure of cardiovascular risk, in patients with IBD . This suggests that effective control of inflammation may reduce cardiovascular risk in these patients.
Original languageEnglish
Pages (from-to)e010942-
Number of pages11
JournalJOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE
Volume8
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease'. Together they form a unique fingerprint.

  • Cite this

    Geraci, G., Pinto, A., Cottone, S., Mule', G., Castellino, P., Torres, D., Pinto, A., Perna, A. F., Ozturk, K., Aykan, M. B., Riguccio, G., Duminuco, A., Inserra, G., Tuttolomondo, A., Fatuzzo, P., Boutouyrie, P., Laurent, S., Cappello, M., Zanoli, L., ... Inserra, G. (2019). Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease. JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE, 8, e010942-.