INCREASED NITROTYROSINE PLASMA LEVELS IN RELATION TO SYSTEMIC MARKERS OF INFLAMMATION AND MYELOPEROXIDASE IN CHRONIC HEART FAILURE.

Francesco Cappello, Giampiero La Rocca, Rita Anzalone, Giovanni Zummo, Antonino Di Stefano, Francesco Tarro Genta, Pantaleo Giannuzzi, Isabella Gnemmi, Ermanno Eleuteri, Fabio Lm Ricciardolo, Francesca Magno, Marilena Colombo, Francesca Magno

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Abstract

The presence of a reciprocal link between inflammation and oxidative/nitrosative stress has been postulated in chronic heart failure(CHF). We aimed to determine signs of nitrosative stress in serum/plasma of CHF patients.ELISA tests were used for quantification of serum/plasma levels of Nitrotyrosine (NT), H2O2, total NO, nitrite (NO2−), myeloperoxidase(MPO), Tumor Necrosis Factor-alpha (TNFα) and pro-Brain Natriuretic Peptide (proBNP) in 66 CHF patients (9 in NYHA I, 34 NYHA II,23 NYHA III) and in 14 age-matched healthy subjects. NT levels were higher in NYHA III CHF patients compared to NYHA II (pb0.05),NYHA I (pb0.03) and controls (pb0.02), whereas NO2− and total NO were higher in NYHA III compared to I (pb0.05 and pb0.04,respectively) and controls (pb0.004 and 0.002) and in NYHA II compared to controls (pb0.04 and pb0.009). NT levels correlatedsignificantly with MPO (r=0.37, pb0.003), TNFα (r=0.32, pb0.01) and proBNP (r=0.32, pb0.01). These data demonstrate an increasedNT plasma level in patients with moderate/severe CHF which is associated to increased levels of markers of systemic inflammation.
Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume135
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Cappello, F., La Rocca, G., Anzalone, R., Zummo, G., Di Stefano, A., Genta, F. T., Giannuzzi, P., Gnemmi, I., Eleuteri, E., Ricciardolo, F. L., Magno, F., Colombo, M., & Magno, F. (2009). INCREASED NITROTYROSINE PLASMA LEVELS IN RELATION TO SYSTEMIC MARKERS OF INFLAMMATION AND MYELOPEROXIDASE IN CHRONIC HEART FAILURE. INTERNATIONAL JOURNAL OF CARDIOLOGY, 135, 386-390.