INCREASED LEVELS OF C-REACTIVE PROTEIN AND FIBRINOGEN INFLUENCE THE RISK OF VASCULAR EVENTS IN PATIENTS WITH NIDDM

Egle Corrado, Salvatore Novo, Giuseppe Coppola, Ida Maria Muratori, Lucio Lo Coco, Rosalba Tantillo

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

AIM: To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes.METHODS: We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death.RESULTS: During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events.CONCLUSION: Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.
Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume106
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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