Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project

Andrea Cortegiani, Santi Maurizio Raineri, Joost Wauters, Guillaume Voiriot, Katrien Lagrou, Ignacio Martin-Loeches, Anna M. Azzini, Philippe Montravers, Cristiano Alicino, Jean-François Timsit, Antonio Vena, Alessio Mesini, Daniele R. Giacobbe, Cecilia Trucchi, Alessia Carnelutti, Silvia Corcione, Maria Merelli, George Dimopoulos, Maria-Panagiota Almyroudi, Mario TumbarelloRoberto Luzzati, Jeroen Schouten, Vaclava Adamkova, Enora Atchade, Valentino Tisa, Simon Dubler, Matteo Bassetti, Polychronis Tasioudis, Stefano Ianniruberto, Riina Rautemaa-Richardson, Matteo Bassetti, Clement Le Bihan, Ana J. Marques, Charlotte H. S. B. Van Den Berg, Riina Rautemaa-Richardson, Clement Le Bihan, Novella Carannante, Pierluigi Brugnaro, Maddalena Peghin, Riina Rautemaa-Richardson, Filippo Ansaldi, Massimo Girardis, José L. García-Garmendia, Manu L. N. G. Malbrain, Oliver A. Cornely, Benoit Veber, Mario Venditti, Bart Jan Kullberg, Herbert Spapen, Massimo Antonelli, José-Artur Paiva, Charlotte H. S. B. Van Den Berg

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59 Citations (Scopus)


Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.
Original languageEnglish
Number of pages0
JournalCritical Care
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine


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