Improving extracellular vesicles visualization: From static to motion

Riccardo Alessandro, Simona Taverna, Marzia Pucci, Pablo Reclusa Asiain, Simona Taverna, Muthukumar Gunasekaran, Peter Verstraelen, Diego De Miguel-Pérez, Nathalie Claes, Pablo Reclusa, Sunjay Kaushal, Isabel Pintelon, Christian Rolfo, Sara Bals, Sunjay Kaushal, Christian Diego Rolfo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects have made them a major field of interest in cancer research. EVs, are able to be internalized through integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progression and pre-metastatic niche formation. However, this specificity might lead to new opportunities in cancer treatment by using EVs as devices for drug delivery. For future applications of EVs in cancer, improved protocols and methods for EVs isolation and visualization are required. Our group has put efforts on developing a protocol able to track the EVs for in vivo internalization analysis. We showed, for the first time, the videos of labeled EVs uptake by living lung cancer cells.
Original languageEnglish
Pages (from-to)6494-
Number of pages9
JournalScientific Reports
Volume10
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • General

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