Impaired energy expenditure and physical activity in children affected by GH deficiency measured by SenseWear Armband: preliminary results.

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Abstract

Background: Influence of growth hormone on energy expenditure and physical performance is clearly known.Objective and hypotheses: The aim of our study is to evaluate the energy expenditure (EE) during physical (PA) and sedentary activities (SA), in a group of children/adolescents affected by growth hormone deficiency (GHD) compared to healthy subjects, using anobjective measure as SenseWear Armband (SWA-BodyMedia).Patients, methods and results: These preliminary data included 13 untreated, consecutive GHD children and adolescents (6 males) (GH peak <10 ng/ml; IGF1 SDS -2.0±0.3) and 10 controls (6 males), age and sex matched. As expected, the GHD group showed statistically lower height (-2.7±0.9 vs 0.4±0.5 SDS), weight (-1.5±1.2 vs 1.1±0.6 SDS) and Body Mass Index (BMI) (-0.1±1.2 vs 0.6±0.2 SDS).The use of SWA demonstrated that the GHD children showed lower Energy expenditure, total (1007±458 vs 1337±125 cal/d;1.7±0.2 vs 1.9±0.2 Mets/d) and active (214±136 vs 435±88 cal/d;7±3 vs 13±4 cal/Kg/d) and spent statistically less time in physical activity (>3 Mets) (1.5 ±0.8 vs 2.3±1 h/d), especially moderate (3-6 Mets)(1.4±0.8 vs 2.2±0.9 h/d; 5.8±3.1 vs 9.2±3.9% of daily hours) compared with healthy subjects.A tendency to spend more time in sedentary activities was found in GHD group (16±4 vs 14±3 h/d), although not statistically significant.In multivariate regression IGF1 and BMISD resulted positive predictors of EE/daily (cal/daily) in GHD children.Conclusions: In conclusion our preliminary results seem to confirm that children affected by growth hormone deficiency showed lowerenergy expenditure as calories/daily and spent less time in physical activities compared to normal children. This result seems correlate toIGF1 values indicating a possible role of GH in physical performance. Further evaluations on greater number of patients, before and after GH therapy, are ongoing to confirm our findings.
Original languageEnglish
Number of pages0
JournalHormone Research in Paediatrics
Volume78
Publication statusPublished - 2012

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