TY - JOUR
T1 - Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
AU - Balistreri, Carmela Rita
AU - Muscoli, Saverio
AU - De Rosa, Salvatore
AU - Selvaggio, Giancarlo
AU - Selvaggio, Stefano
AU - Ferdinandy, Péter
AU - Madonna, Rosalinda
AU - Ferdinandy, Péter
AU - De Caterina, Raffaele
PY - 2019
Y1 - 2019
N2 - Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
AB - Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
UR - http://hdl.handle.net/10447/361587
M3 - Article
SN - 2077-0383
VL - 8
SP - 98-
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -