IMMUNOLOGICAL ASPECTS OF CROHN'S DISEASE: A REGULATORY FUNCTION OF TIM-3/GALECTIN-9 IN LYTH1.

Angelo Leone, Francesco Carini, Giovanni Tomasello, Francesca Rappa, Sabrina David, Margherita Mazzola, Raymond Zerbe, Abdo Jurjus

Research output: Contribution to journalArticle

Abstract

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors. The interaction of these factors causes an imbalance of the microbiota, leading to the activation of several immunological and inflammatory mechanism. From an immunological point of view, there seems to be an involvement of the TIM-3/GALECTIN-9 pathway and of the autoregulation of lyTh1. These studies show that in patients with CD the autoregulation of lyth1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reason for the state of perpetual activation of lyTh1, resulting in the chronic inflammation process.
Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalEuroMediterranean Biomedical Journal
Volume12
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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