Immunohistochemical study on dystrophin expression in CAD-related sudden cardiac death: a marker of early myocardial ischaemia

Elvira Ventura Spagnolo, Cristina Mondello, Luigi Cardia, Alessio Asmundo, Giovanni Bartoloni

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The aims of this study were to assess if dystrophin can be a tool for the forensic evaluation of sudden cardiac death due to coronary atherosclerotic disease (CAD) and particularly if it can be a marker of early myocardial ischaemia. Then in this investigation, the dystrophin was compared to C5b-9 and fibronectin to analyze if there are some differences in the expression of these proteins. Two groups of CAD-related sudden cardiac death, respectively the group 1 with gross and/or histological evidence and the group 2 with no specific histological signs of myocardial ischaemia were used. A third group formed by cases of acute mechanical asphyxiation was used as a control. The immunohistochemical staining by dystrophin, C5b-9 and fibronectin antibodies was performed. Loss of sarcolemmal dystrophin was observed in different degrees according to more or less significant histological evidence of myocardial ischaemia. Moreover, the comparison between loss of dystrophin expression and fibronectin positivity showed significant differences in group 2. The results suggested that dystrophin can be used in forensic diagnosis of CAD-related sudden cardiac death and as marker of early myocardial ischaemia.
Original languageEnglish
Pages (from-to)1333-1339
Number of pages7
JournalInternational Journal of Legal Medicine
Volume132
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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