Identification of Three Particular MorphologicalPhenotypes in Sporadic Thoracic Aortic Aneurysm:Phenotype III As Sporadic Thoracic AorticAneurysm Biomarker in Aged Individuals

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Abstract

AbstractAging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e.,aorta), resulting in a multitude of changes at different structural and functional levels. As result, medialdegeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA),whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypeswere researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemicalanalyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevatedcystic MD, plurifocal medial apoptosis, and increased metalloproteinase-9 amount characterize it. In addition,it was significantly correlated with the severity of elastic fragmentation, hypertension, and smoking, andparticularly with advancing age. Thus, phenotype III might represent the typical MD phenotype associated withS-TAA in old people that have a major risk of aorta rupture and dissection independently on aneurysmdiameter. This might permit the assumption that phenotype III with its typical histological abnormalities is anoptimal biomarker of rupture and/or dissection in aged individuals and is useful both for applying differentsurgical approaches and providing appropriate surgical indications
Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalRejuvenation Research
Volume17
Publication statusPublished - 2014

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Thoracic Aortic Aneurysm
Thorax
Biomarkers
Phenotype
Aorta
Dissection
Rupture
Metalloproteases
Blood Vessels
Arteries
Smoking
Apoptosis
Hypertension

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this

@article{3a6f304905d5456badcb5958d4058a35,
title = "Identification of Three Particular MorphologicalPhenotypes in Sporadic Thoracic Aortic Aneurysm:Phenotype III As Sporadic Thoracic AorticAneurysm Biomarker in Aged Individuals",
abstract = "AbstractAging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e.,aorta), resulting in a multitude of changes at different structural and functional levels. As result, medialdegeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA),whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypeswere researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemicalanalyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevatedcystic MD, plurifocal medial apoptosis, and increased metalloproteinase-9 amount characterize it. In addition,it was significantly correlated with the severity of elastic fragmentation, hypertension, and smoking, andparticularly with advancing age. Thus, phenotype III might represent the typical MD phenotype associated withS-TAA in old people that have a major risk of aorta rupture and dissection independently on aneurysmdiameter. This might permit the assumption that phenotype III with its typical histological abnormalities is anoptimal biomarker of rupture and/or dissection in aged individuals and is useful both for applying differentsurgical approaches and providing appropriate surgical indications",
author = "Calogero Caruso and Balistreri, {Carmela Rita} and Loredana Vaccarino and Giuseppina Candore and Domenico Lio and Emiliano Maresi and Calogera Pisano",
year = "2014",
language = "English",
volume = "17",
pages = "192--196",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",

}

TY - JOUR

T1 - Identification of Three Particular MorphologicalPhenotypes in Sporadic Thoracic Aortic Aneurysm:Phenotype III As Sporadic Thoracic AorticAneurysm Biomarker in Aged Individuals

AU - Caruso, Calogero

AU - Balistreri, Carmela Rita

AU - Vaccarino, Loredana

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Maresi, Emiliano

AU - Pisano, Calogera

PY - 2014

Y1 - 2014

N2 - AbstractAging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e.,aorta), resulting in a multitude of changes at different structural and functional levels. As result, medialdegeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA),whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypeswere researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemicalanalyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevatedcystic MD, plurifocal medial apoptosis, and increased metalloproteinase-9 amount characterize it. In addition,it was significantly correlated with the severity of elastic fragmentation, hypertension, and smoking, andparticularly with advancing age. Thus, phenotype III might represent the typical MD phenotype associated withS-TAA in old people that have a major risk of aorta rupture and dissection independently on aneurysmdiameter. This might permit the assumption that phenotype III with its typical histological abnormalities is anoptimal biomarker of rupture and/or dissection in aged individuals and is useful both for applying differentsurgical approaches and providing appropriate surgical indications

AB - AbstractAging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e.,aorta), resulting in a multitude of changes at different structural and functional levels. As result, medialdegeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA),whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypeswere researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemicalanalyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevatedcystic MD, plurifocal medial apoptosis, and increased metalloproteinase-9 amount characterize it. In addition,it was significantly correlated with the severity of elastic fragmentation, hypertension, and smoking, andparticularly with advancing age. Thus, phenotype III might represent the typical MD phenotype associated withS-TAA in old people that have a major risk of aorta rupture and dissection independently on aneurysmdiameter. This might permit the assumption that phenotype III with its typical histological abnormalities is anoptimal biomarker of rupture and/or dissection in aged individuals and is useful both for applying differentsurgical approaches and providing appropriate surgical indications

UR - http://hdl.handle.net/10447/91884

M3 - Article

VL - 17

SP - 192

EP - 196

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

ER -