Abstract

Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerative diseases. Not all of patients with Mild Cognitive Impairment (MCI) finally develop dementia and it is interesting to investigate the role of possible markers for early diagnosis. Hyperhomocysteinemia is associated to several pathologies including cognitive impairment; aim of this study is to evaluate the correlation between cognitive performance assessment and homocysteine plasma levels. Total 74 patients and 75 healthy controls were enrolled and MCI were defined by a MMSE score lower than 26 after adjustment for years of schooling. Homocysteine plasma levels were determined. Homocysteine levels significantly raised in patients with cognitive impairment and showed a significant negative association with MMSE score. Finally, our data show that a moderate risk of cognitive impairment could be associated to high homocysteine plasma levels.
Original languageEnglish
Pages (from-to)1337-1340
Number of pages4
JournalRESEARCH JOURNAL OF BIOLOGICAL SCIENCES
Volume3
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'Hyperhomocysteinemia in patients with cognitive impairment'. Together they form a unique fingerprint.

Cite this