Hyaluronic-based antibacterial hydrogel coating for implantable biomaterials in orthopedics and trauma. From basic research to clinical applications.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs.Antibacterial coating of implants has been advocated by many experts as a possible solution toreduce the burden of implant-related infection and several different solutions have been proposed in the last decades. However, while most of the investigated technologies have showntheir efficacy in vitro and/or in vivo, only few were able to reach the market, due to clinical,industrial, economic and regulatory issues. Hyaluronic acid composites have been previouslyshown to possess antifouling capabilities and have been used in various clinical settings toreduce bacterial adhesion and mitigate biofilm-related infections. Recently, a fast-resorbable,hyaluronic-based hydrogel coating was developed to protect implanted biomaterials in orthopedics, trauma and maxillofacial surgery. Preclinical and clinical testing did show the safetyand efficacy of the device that can be intraoperatively loaded with one or more antibiotics anddirectly applied by the surgeon to the implant surface, at the time of surgery. Here, we reviewthe current evidence concerning this very first antibacterial coating of implants and outline theeconomic impact of the possible large-scale application of this technology.
Original languageEnglish
Title of host publicationHYALURONIC-BASED ANTIBACTERIAL HYDROGEL COATING FOR IMPLANTABLE BIOMATERIALS IN ORTHOPEDICS AND TRAUMA: FROM BASIC RESEARCH TO CLINICAL APPLICATIONS
Pages179-200
Number of pages22
Publication statusPublished - 2018

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Giammona, G., Palumbo, F. S., & Pitarresi, G. (2018). Hyaluronic-based antibacterial hydrogel coating for implantable biomaterials in orthopedics and trauma. From basic research to clinical applications. In HYALURONIC-BASED ANTIBACTERIAL HYDROGEL COATING FOR IMPLANTABLE BIOMATERIALS IN ORTHOPEDICS AND TRAUMA: FROM BASIC RESEARCH TO CLINICAL APPLICATIONS (pp. 179-200)