Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery

Gaetano Giammona, Mariano Licciardi, Laura Modica De Mohac, Marco Paolino, Gemma Leone, Annalisa Reale, Maurizio Anzini, Hartmut Komber, Alessandro Donati, Andrea Cappelli, Agnese Magnani, Germano Giuliani

Research output: Contribution to journalArticlepeer-review

Abstract

In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OAandHA-FA-HEG-SAderivatives showed the property to create self-assembled cytocompatible nanostructured aggregates in water, thanks to the simultaneous presence of hydrophilic portions in the polymeric backbone, such as hyaluronic acid, and hydrophobic portions in the side chains. Furthermore, the designed materials interact with living cells showing a high degree of cytocompatibility. The potential ability of nanosystems to load pharmacologically active molecules was assessed by the physical entrapment of olanzapine into both polymeric systems. The drug loading evaluation demonstrated that the nanoparticles are able to incorporate a good quantity of olanzapine, as well as improve drug solubility, release profile, and cytocompatibility.
Original languageEnglish
Pages (from-to)1-20
Number of pages20
JournalPharmaceutics
Volume11
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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