Human Papillomavirus Infection: A Risk Factor for Oral and Oropharyngeal Cancers

Research output: Chapter in Book/Report/Conference proceedingChapter


A wide range of human papillomavirus (HPV) prevalence datais now available for head and neck squamous cell carcinomas(HNSCCs), especially for those cancers originating from theepithelial lining of the upper aero-digestive tract (UADT) (i.e.,the pharynx, the larynx, and the oral cavity). There is strongevidence that supports HPV as an etiological cause of headand neck carcinogenesis particularly for distinct oropharyngealsubsites. A specific molecular, histopathological, clinical,and prognostic profile is intimately connected with HPVinfection. While the role of HPV in oropharyngeal carcinogenesisis firmly acknowledged, its role in oral cancer is currentlybeing debated. Several recent studies suggest the importanceof correctly distinguishing HNSCCs by subsites, andutilizing more sensitive HPV-DNA detection techniques, indesigning future studies. Defining the HPV status of thetumor aids in the correct management of patients with oropharyngealcancers.
Original languageEnglish
Title of host publicationTextbook of Oral Cancer. Prevention, Diagnosis and Management
Number of pages15
Publication statusPublished - 2020


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