Hsp60 Inhibitors and Modulators

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we focus on the 60 KDa Heat Shock Protein (Hsp60) and discuss some of its biological, molecular and pathological features. The structural and mechanistic aspect of the Hsp60 folding cycle will be also presented. We further illustrate how Hsp60 may be involved in many diseases and therefore considered as an effective therapeutic or theranostic target. Finally, the state-of-the-art on the development of Hsp60 and bacterial GroEL inhibitors and modulators of their expression will be illustrated. This is discussed in the light of a negative chaperonotherapy, and the consequent development of inhibitors, as well as positive chaperonotherapy, in the event its excessive activity is a disease-contrasting event.
Original languageEnglish
Title of host publicationHeat Shock Protein 60 in Human diseases and disorders
Pages27-39
Number of pages13
Publication statusPublished - 2019

Publication series

NameHEAT SHOCK PROTEINS

Fingerprint Dive into the research topics of 'Hsp60 Inhibitors and Modulators'. Together they form a unique fingerprint.

  • Cite this

    Buscemi, S., Palumbo Piccionello, A., Marzullo, P., & Pace, A. (2019). Hsp60 Inhibitors and Modulators. In Heat Shock Protein 60 in Human diseases and disorders (pp. 27-39). (HEAT SHOCK PROTEINS).