Hippocampal reversible lesions in a case of transient global amnesia

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Abstract

We report the case of 55-year-old man that after an emotional stress showed retrograde and anterograde amnesia with impairment of orientation in space and time but undisturbed consciousness. A neurological examination excluded other neurological signs or symptoms. The amnesic syndrome resolved spontaneously within 24 hours and the hypothesis of transient global amnesia was placed. Brain CT scan and conventional MRI sequences did not show any relevant pathological findings but diffusion-weighted imaging (DWI) showed two millimetric bright spot of restricted diffusion in the right hippocampus; in a brain MRI follow-up those findings were no more appreciable. The diagnosis of transient global amnesia is primarily clinical, and MRI can give a positive diagnostic support. For a best detection of lesions is very important to respect the right time of imaging and the optimal DWI protocol. Here we highlight the importance of a prompted, well-timed imaging and an appropriate protocol, to ensure a correct and defined detection of the lesions.
Original languageEnglish
Pages (from-to)661-666
Number of pages6
JournalGAZZETTA MEDICA ITALIANA. ARCHIVIO PER LE SCIENZE MEDICHE
Volume177
Publication statusPublished - 2018

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Transient Global Amnesia
Anterograde Amnesia
Retrograde Amnesia
Neurologic Examination
Brain
Consciousness
Psychological Stress
Signs and Symptoms
Hippocampus
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Hippocampal reversible lesions in a case of transient global amnesia",
abstract = "We report the case of 55-year-old man that after an emotional stress showed retrograde and anterograde amnesia with impairment of orientation in space and time but undisturbed consciousness. A neurological examination excluded other neurological signs or symptoms. The amnesic syndrome resolved spontaneously within 24 hours and the hypothesis of transient global amnesia was placed. Brain CT scan and conventional MRI sequences did not show any relevant pathological findings but diffusion-weighted imaging (DWI) showed two millimetric bright spot of restricted diffusion in the right hippocampus; in a brain MRI follow-up those findings were no more appreciable. The diagnosis of transient global amnesia is primarily clinical, and MRI can give a positive diagnostic support. For a best detection of lesions is very important to respect the right time of imaging and the optimal DWI protocol. Here we highlight the importance of a prompted, well-timed imaging and an appropriate protocol, to ensure a correct and defined detection of the lesions.",
keywords = "Diffusion-weighted magnetic resonance imaging, Hippocampus, Medicine (all), Memory, Transient global amnesia",
author = "{La Tona}, Giuseppe and Cesare Gagliardo and Carla Cannizzaro and Roberto Lagalla and Fabio Barone and Giuseppe Salvaggio",
year = "2018",
language = "English",
volume = "177",
pages = "661--666",
journal = "Gazzetta Medica Italiana Archivio per le Scienze Mediche",
issn = "0393-3660",
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TY - JOUR

T1 - Hippocampal reversible lesions in a case of transient global amnesia

AU - La Tona, Giuseppe

AU - Gagliardo, Cesare

AU - Cannizzaro, Carla

AU - Lagalla, Roberto

AU - Barone, Fabio

AU - Salvaggio, Giuseppe

PY - 2018

Y1 - 2018

N2 - We report the case of 55-year-old man that after an emotional stress showed retrograde and anterograde amnesia with impairment of orientation in space and time but undisturbed consciousness. A neurological examination excluded other neurological signs or symptoms. The amnesic syndrome resolved spontaneously within 24 hours and the hypothesis of transient global amnesia was placed. Brain CT scan and conventional MRI sequences did not show any relevant pathological findings but diffusion-weighted imaging (DWI) showed two millimetric bright spot of restricted diffusion in the right hippocampus; in a brain MRI follow-up those findings were no more appreciable. The diagnosis of transient global amnesia is primarily clinical, and MRI can give a positive diagnostic support. For a best detection of lesions is very important to respect the right time of imaging and the optimal DWI protocol. Here we highlight the importance of a prompted, well-timed imaging and an appropriate protocol, to ensure a correct and defined detection of the lesions.

AB - We report the case of 55-year-old man that after an emotional stress showed retrograde and anterograde amnesia with impairment of orientation in space and time but undisturbed consciousness. A neurological examination excluded other neurological signs or symptoms. The amnesic syndrome resolved spontaneously within 24 hours and the hypothesis of transient global amnesia was placed. Brain CT scan and conventional MRI sequences did not show any relevant pathological findings but diffusion-weighted imaging (DWI) showed two millimetric bright spot of restricted diffusion in the right hippocampus; in a brain MRI follow-up those findings were no more appreciable. The diagnosis of transient global amnesia is primarily clinical, and MRI can give a positive diagnostic support. For a best detection of lesions is very important to respect the right time of imaging and the optimal DWI protocol. Here we highlight the importance of a prompted, well-timed imaging and an appropriate protocol, to ensure a correct and defined detection of the lesions.

KW - Diffusion-weighted magnetic resonance imaging

KW - Hippocampus

KW - Medicine (all)

KW - Memory

KW - Transient global amnesia

UR - http://hdl.handle.net/10447/328689

UR - https://www.minervamedica.it/en/getpdf/Nx1h6iYOMTeVoXf9ViqKgvTSs0V7SbH59j6%252FdJG%252BF7qyw9Dnzf6mREcj2H9ZUsY0fGCofOYbw%252Blg4KRXFrzbgg%253D%253D/R22Y2018N11A0661.pdf

M3 - Article

VL - 177

SP - 661

EP - 666

JO - Gazzetta Medica Italiana Archivio per le Scienze Mediche

JF - Gazzetta Medica Italiana Archivio per le Scienze Mediche

SN - 0393-3660

ER -