High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400

Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G.

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration. MATERIAL AND METHODS: Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11 years) with suspected coronary artery disease were randomized to 2 groups to receive 100 mL of either iopromide 370 (group 1: Ultravist 370, 370 mg iodine/mL; Schering AG, Berlin, Germany) or iomeprol 400 (group 2: Iomeron 400, 400 mg iodine/mL; Bracco Imaging SpA, Milan, Italy). Both CM were administered at a rate of 4 mL/s. All patients underwent 16-MSCT coronary angiography (Sensation 16; Siemens, Germany) with collimation 16 × 0.75 mm and rotation time 375 ms. The attenuation in Hounsfield units (HU) achieved after each CM was determined at regions of interest (ROIs) placed at the origin of coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery. Differences in mean attenuation in the coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery were evaluated using Student t test. RESULTS: The mean attenuation achieved at each anatomic site was consistently greater after iomeprol 400 than after iopromide 370. At the origin of coronary arteries, the mean attenuation after iomeprol 400 (340 ± 53 HU) was greater (P < 0.05) than that after iopromide 370 (313 ± 42 HU). Similar findings were noted for the mean attenuation in the ascending aorta, descending aorta, and pulmonary artery. CONCLUSION: The intravenous administration of iomeprol 400 provides higher attenuation of the coronary arteries and of the great arteries of the thorax as compared with iopromide 370 using the same injection parameters. Copyright © 2006 by Lippincott Williams & Wilkins
Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalInvestigative Radiology
Volume41
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G. (2006). High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. Investigative Radiology, 41, 349-353.

High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. / Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G.

In: Investigative Radiology, Vol. 41, 2006, p. 349-353.

Research output: Contribution to journalArticle

Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G. 2006, 'High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400', Investigative Radiology, vol. 41, pp. 349-353.
Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G. High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. Investigative Radiology. 2006;41:349-353.
Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G. / High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. In: Investigative Radiology. 2006 ; Vol. 41. pp. 349-353.
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abstract = "OBJECTIVE: The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration. MATERIAL AND METHODS: Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11 years) with suspected coronary artery disease were randomized to 2 groups to receive 100 mL of either iopromide 370 (group 1: Ultravist 370, 370 mg iodine/mL; Schering AG, Berlin, Germany) or iomeprol 400 (group 2: Iomeron 400, 400 mg iodine/mL; Bracco Imaging SpA, Milan, Italy). Both CM were administered at a rate of 4 mL/s. All patients underwent 16-MSCT coronary angiography (Sensation 16; Siemens, Germany) with collimation 16 × 0.75 mm and rotation time 375 ms. The attenuation in Hounsfield units (HU) achieved after each CM was determined at regions of interest (ROIs) placed at the origin of coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery. Differences in mean attenuation in the coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery were evaluated using Student t test. RESULTS: The mean attenuation achieved at each anatomic site was consistently greater after iomeprol 400 than after iopromide 370. At the origin of coronary arteries, the mean attenuation after iomeprol 400 (340 ± 53 HU) was greater (P < 0.05) than that after iopromide 370 (313 ± 42 HU). Similar findings were noted for the mean attenuation in the ascending aorta, descending aorta, and pulmonary artery. CONCLUSION: The intravenous administration of iomeprol 400 provides higher attenuation of the coronary arteries and of the great arteries of the thorax as compared with iopromide 370 using the same injection parameters. Copyright {\circledC} 2006 by Lippincott Williams & Wilkins",
author = "{Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G.} and Massimo Midiri and Roberto Lagalla and Giuseppe Runza",
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T1 - High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400

AU - Cademartiri, F.; De Monye, C.; Pugliese, F.; Mollet, N.; Van Der Lugt, A.; De Feyter, P.; Krestin, G.

AU - Midiri, Massimo

AU - Lagalla, Roberto

AU - Runza, Giuseppe

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration. MATERIAL AND METHODS: Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11 years) with suspected coronary artery disease were randomized to 2 groups to receive 100 mL of either iopromide 370 (group 1: Ultravist 370, 370 mg iodine/mL; Schering AG, Berlin, Germany) or iomeprol 400 (group 2: Iomeron 400, 400 mg iodine/mL; Bracco Imaging SpA, Milan, Italy). Both CM were administered at a rate of 4 mL/s. All patients underwent 16-MSCT coronary angiography (Sensation 16; Siemens, Germany) with collimation 16 × 0.75 mm and rotation time 375 ms. The attenuation in Hounsfield units (HU) achieved after each CM was determined at regions of interest (ROIs) placed at the origin of coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery. Differences in mean attenuation in the coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery were evaluated using Student t test. RESULTS: The mean attenuation achieved at each anatomic site was consistently greater after iomeprol 400 than after iopromide 370. At the origin of coronary arteries, the mean attenuation after iomeprol 400 (340 ± 53 HU) was greater (P < 0.05) than that after iopromide 370 (313 ± 42 HU). Similar findings were noted for the mean attenuation in the ascending aorta, descending aorta, and pulmonary artery. CONCLUSION: The intravenous administration of iomeprol 400 provides higher attenuation of the coronary arteries and of the great arteries of the thorax as compared with iopromide 370 using the same injection parameters. Copyright © 2006 by Lippincott Williams & Wilkins

AB - OBJECTIVE: The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration. MATERIAL AND METHODS: Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11 years) with suspected coronary artery disease were randomized to 2 groups to receive 100 mL of either iopromide 370 (group 1: Ultravist 370, 370 mg iodine/mL; Schering AG, Berlin, Germany) or iomeprol 400 (group 2: Iomeron 400, 400 mg iodine/mL; Bracco Imaging SpA, Milan, Italy). Both CM were administered at a rate of 4 mL/s. All patients underwent 16-MSCT coronary angiography (Sensation 16; Siemens, Germany) with collimation 16 × 0.75 mm and rotation time 375 ms. The attenuation in Hounsfield units (HU) achieved after each CM was determined at regions of interest (ROIs) placed at the origin of coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery. Differences in mean attenuation in the coronary arteries and on the ascending aorta, descending aorta, and pulmonary artery were evaluated using Student t test. RESULTS: The mean attenuation achieved at each anatomic site was consistently greater after iomeprol 400 than after iopromide 370. At the origin of coronary arteries, the mean attenuation after iomeprol 400 (340 ± 53 HU) was greater (P < 0.05) than that after iopromide 370 (313 ± 42 HU). Similar findings were noted for the mean attenuation in the ascending aorta, descending aorta, and pulmonary artery. CONCLUSION: The intravenous administration of iomeprol 400 provides higher attenuation of the coronary arteries and of the great arteries of the thorax as compared with iopromide 370 using the same injection parameters. Copyright © 2006 by Lippincott Williams & Wilkins

UR - http://hdl.handle.net/10447/27585

M3 - Article

VL - 41

SP - 349

EP - 353

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

ER -