HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

Eugenio Fiorentino, Stefano Caruso, Fabrizio Bronte, Viviana Bazan, Daniele Fanale, Giuseppe Bronte, Antonio Russo, Christian Rolfo, Christian Diego Rolfo, Enrico Bronte, Maria Grazia Bavetta

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The diagnosis and treatment of hepatocellular carcinoma (HCC) underwent a huge advancement in the last years. Recently, microRNAs (miRNAs) have been also studied to provide a new tool for early diagnosis of high risk patients, for prognostic classification to identify those patients who benefit cancer treatment and for predictive definition to select the right targeted drug.In this review we revised all the available data obtained to explore the role of miRNAs in HCC. This analysis led to identification of miRNAs which could gain a diagnostic, prognostic or predictive role.The results of studies on miRNAs involved in HCC are initial and far from providing scientific evidences to translate into clinical practice. We propose a classification of these miRNAs, that we could name HepatomiRNoma as a whole. Anyway prospective studies have to be designed to clarify the real clinical impact of this new tool.
Original languageEnglish
Pages (from-to)312-321
Number of pages10
JournalCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume97
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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