Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Vincenza Calvaruso, Anna Licata, Valeria Raparelli, Vincenzo La Mura, Laura Napoleone, Sergio Maimone, Vincenza Calvaruso, Paolo Angeli, Armando Tripodi, Francesco Violi, Agostino Colli, Pier Mannuccio Mannucci, Cristina Lucidi, Salvatore Piano, Erica Villa, Antonella Scalera, Domenico Ferro, Massimo Zuin, Oliviero Riggio, Marco SenzoloMassimo Sicilianom, Anna Licata, Maria Teresa Sartori, Gianluca Svegliati Baroni, Marco Marzioni, Lesley De Pietri, Paolo Feltracco, Filippo Schepis, Massimo Primignani, Filomena Morisco, Antonella Tufano, Paolo Caraceni, Fabio Piscaglia, David Sacerdoti, Marco Marietta, Paolo Rebulla, Angelo Andriulli, Daniele Prati, Stefania Basili, Giovanni Di Minno, Domenico Ferro, Elvira Grandone, Carlo Merkel, Marco Falcone, Edoardo G. Giannini, Alessandro Vitale, Dario Ribero

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Patients with cirrhosis present with hemostatic alterations secondary to reduced availability of pro-coagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent jury. The statements presented here highlight strengths and weaknesses of current laboratory tests to assess bleeding and thrombotic risk in cirrhotic patients, the pathophysiology of hemostatic perturbations in this condition, and outline the optimal management of bleeding and thrombosis in patients with liver cirrhosis.
Original languageEnglish
Pages (from-to)455-467
Number of pages13
JournalDigestive and Liver Disease
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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