Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report

Ada Maria Florena, Antonino Terranova, Maurizio Soresi, Lydia Giannitrapani, Andrea Affronti, Fania Puccia, Vania Lombardo

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Abstract

Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalItalian Journal of Medicine
Volume12
Publication statusPublished - 2018

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Hemophagocytic Lymphohistiocytosis
Tuberculosis
Mycobacterium tuberculosis
Fever
Pancytopenia
Mycobacterium Infections
Sudan
Molecular Epidemiology
Bronchoalveolar Lavage
Diarrhea
Immune System
Lymphoma
Spleen
Lymph Nodes
Bone Marrow
Tomography
Biopsy
Lung
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report. / Florena, Ada Maria; Terranova, Antonino; Soresi, Maurizio; Giannitrapani, Lydia; Affronti, Andrea; Puccia, Fania; Lombardo, Vania.

In: Italian Journal of Medicine, Vol. 12, 2018, p. 61-66.

Research output: Contribution to journalArticle

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AU - Puccia, Fania

AU - Lombardo, Vania

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AB - Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly

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