Background: Early detecting AMI in individuals presenting to the ED with chest pain continues to be a challenge. cTn is the gold standard for AMI diagnosis but early presenters (<1 hours from symptom onset) maybe cTn negative on admission. We analysed the diagnostic value of h-FABP and hs-TnI in patients presenting to ED with chest pain and no cTnI elevations. Methods: 28 AMI and 28 no-AMI individuals both presented to ED within one hour from pain onset were included. Blood donors were analysed for h-FABP cut-off identification. Among AMI patients, 55% were positive for h-FABP and 34.6% were positive for hs-TnI (p = .015), thus 21% were positive only for h-FABP. The diagnostic accuracy was assessed by ROC curve. h-FABP showed a higher sensitivity but lower specificity than hs-TnI. Conclusions: In our study, the frequency of h-FABP positivity among AMI patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI AUC was superior to that of h-FABP. These preliminary findings might confirm that h-FABP may be a good candidate for AMI rule-in/rule-out within the ED context.
|Number of pages||5|
|Journal||SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION|
|Publication status||Published - 2017|
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
Bellia, C., Ciaccio, M., Scazzone, C., Bivona, G., Agnello, L., Novo, G., Lo Sasso, B., Ciaccio, M., Muratore, R., Levantino, P., & Muratore, R. (2017). Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1-5.