Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone

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Abstract

Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society.
Original languageEnglish
Pages (from-to)81-94
Number of pages14
JournalPharmacological Research Communications
Volume11
Publication statusPublished - 1979

All Science Journal Classification (ASJC) codes

  • Pharmacology

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