Graph-theoretical derivation of brain structural connectivity

Giuseppe Giacopelli, Domenico Tegolo, Giuseppe Giacopelli, Giacopelli, Michele Migliore

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Brain connectivity at the single neuron level can provide fundamental insights into how information is integrated and propagated within and between brain regions. However, it is almost impossible to adequately study this problem experimentally and, despite intense efforts in the field, no mathematical description has been obtained so far. Here, we present a mathematical framework based on a graph-theoretical approach that, starting from experimental data obtained from a few small subsets of neurons, can quantitatively explain and predict the corresponding full network properties. This model also changes the paradigm with which large-scale model networks can be built, from using probabilistic/empiric connections or limited data, to a process that can algorithmically generate neuronal networks connected as in the real system.
Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalApplied Mathematics and Computation
Volume377
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Computational Mathematics
  • Applied Mathematics

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