GLP-2: What do we know? What are we going to discover?

Antonella Amato, Sara Baldassano, Sara Baldassano, Antonella Amato

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells ofthe intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in theneurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanismof action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now revivingbased on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it alsoseems to be involved in glucose homeostasis.The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the entericmodulation of the gastrointestinal function and to focus on new works in order to present an innovative pictureof GLP-2.
Original languageEnglish
Number of pages5
JournalRegulatory Peptides
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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