Genetic Control of Immune Response in Carriers of the 8.1 Ancestral Haplotype: Correlation with Levels of IgG Subclasses: Its Relevance in the Pathogenesis of Autoimmune Diseases

Giuseppina Candore, Calogero Caruso, Irene Cuppari, Anna Maria Campagna, Daniele D.I. Carlo, Claudia Mineo, Calogero Caruso, Anna Maria Campagna, Daniele Di Carlo, Irene Cuppari

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we demonstrate that IgG2 serum levels were significantly lower in 8.1 AH carriers than in 8.1 AH non-carriers. On the contrary, as regards IgG1, IgG3, IgG4 serum levels, no significant differences were observed between the two groups. In AH 8.1 carriers low IgG2 levels might take to slower clearance of the infectious agent and hence to a lasting presence of it. The persistence of infectious antigens could determine an increased production of autoantibodies with a higher risk of cross-reactions.
Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1110
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'Genetic Control of Immune Response in Carriers of the 8.1 Ancestral Haplotype: Correlation with Levels of IgG Subclasses: Its Relevance in the Pathogenesis of Autoimmune Diseases'. Together they form a unique fingerprint.

Cite this