Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program

Liana Bosco, Maria Carmela Roccheri, Claudio Luparello, Monica Lispi, Stefania Ferrari, Daniele Santi, Domenico Valerio, Giovanni Ruvolo, Paola Piomboni, Elena Sarcina

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Abstract

FSH receptor (FSHR) Ala307Thr and Asn680Ser and LHβ chain (LHB) Trp28Arg and Ile35Thr polymorphisms affect the response to pharmacological ovarian stimulation with r-FSH in women undergoing assisted reproductive treatment (ART). Here, we evaluated the expression level of selected genes involved in follicle maturation and the possible onset of apoptosis in cumulus cells of patients with single and double FSHR and LHB polymorphisms, as potential markers of oocyte competence.
Original languageEnglish
Pages (from-to)2391-2404
Number of pages14
JournalCellular Physiology and Biochemistry
Volume43
Publication statusPublished - 2017

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All Science Journal Classification (ASJC) codes

  • Physiology

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