FUNZIONALIZZAZIONE E CARATTERIZZAZIONE DI NANOTUBI DI ALLOSITE UTILIZZATI PER LO STUDIO DELL’INCAPSULAMENTO DI DERIVATI FENOLICI

Research output: Contribution to conferenceOther

Abstract

[automatically translated] Phenolic compounds are part of the secondary metabolites of plants and among these curcumin has been extensively studied for its intrinsic properties farmacologiche.1-4 Curcumin [bis (4-hydroxy-3-methoxy-phenyl) -1,6-heptadiene -3,5-dione] in the form of yellow pigment isolated from turmeric dry longa rhizome was used in the presence of delivery systems for applications farmaceutiche.5 One of the disadvantages of curcumin is its poor bioavailability in an aqueous environment; 6 problem that can be solved by encapsulating it in nanocontainers. Among the natural nanodelivery systems that do not exhibit cytotoxicity there are the allosite nanotubes. The allosite nanotubes have been used by Price and Lvov as molecules that can encapsulate medications. 7 In addition, this ability can be improved through the functionalization of both the internal and external surface of the nanotubes themselves. In this communication we report preliminary data on encapsulation of curcumin in allosite nanotubes modified or not, with the future aim to test such systems in vitro on breast cancer cells
Original languageItalian
Number of pages1
Publication statusPublished - 2013

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