Focused ultrasound in neuroscience. State of the art and future perspectives

Giuseppe Roberto Giammalva, Ludovico La Grutta, Cesare Gagliardo, Domenico Iacopino, Rosario Maugeri, Francesca Graziano, Carlo Gulì, Kaan Yağmurlu, Maria Angela Pino, Giuseppe Emmanuele Umana, Federico Midiri, Luigi Basile, Rosa Maria Gerardi, Giuseppe Roberto Giammalva, Gianluca Scalia, Domenico Messina, Domenico Gerardo Iacopino, Bipin Chaurasia, Federica Paolini, Domenico MessinaSalvatore Marrone, Cesare Gagliardo, Silvana Tumbiolo, Federica Paolini, Federico Midiri, Salvatore Marrone, Susanna Tumbiolo

Research output: Contribution to journalArticlepeer-review


Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a noninvasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalBrain Sciences
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • General Neuroscience


Dive into the research topics of 'Focused ultrasound in neuroscience. State of the art and future perspectives'. Together they form a unique fingerprint.

Cite this