Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment

Fabio Caradonna, Carla Gentile, Daniele Bellavia, Angela De Luca, Valeria Carina, Viviana Costa, Gianluca Giavaresi, Lavinia Raimondi, Milena Fini, Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Valeria Carina

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP).
Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalTrends in Endocrinology and Metabolism
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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