Fetuin-A is a circulating inhibitor of ectopic calcification in vivo; it is decreased in patients with chronic kidney disease and correlates with glomerular filtration rate in patients with coronary artery disease. However, serum levels of Fetuin-A has not been described in elderly. Aim of the study was to evaluate Fetuin-A serum levels together with AHSG T256S genotype in a population of healthy elderly. Serum fetuin-A levels were determined by ELISA. T256S polymorphism of AHSG gene was determined by PCR-RFLP.Serum Fetuin-A was 0,38 ± 0,13 g/l in the group composed by 206 healthy centenarians. Moreover, subjects with at least one S allele had lower Fetuin-A levels (P<001). Interestingly, Fetuin-A was associated with increasing age (r=0.159; p=0.027; adjusted for sex).Fetuin-A increases with age in successful aging, suggesting a protective effect against vascular calcification exerted by Fetuin-A. Our results confirm T256S polymorphism as a genetic determinant of plasma fetuin-A levels.
|Title of host publication||Medical Biotechnologies and Forensic Medicine Review|
|Number of pages||6|
|Publication status||Published - 2011|