FATTORI ASSOCIATI ALLA DISCORDANZA TRA ALTERAZIONI DELLA PULSE WAVE VELOCITY AORTICA E AUMENTO DELLO SPESSORE MIO-INTIMALE CAROTIDEO IN SOGGETTI IPERTESI: DATI PRELIMINARI

Giuseppe Mule', Calogero Geraci, Santina Cottone, Giulio Geraci, Francesco D'Ignoto, Manuela Mogavero, Maria Giovanna Vario

Research output: Contribution to conferenceOther

Abstract

[automatically translated] Numerous studies have shown that the thickness of the carotid intima-My (IMTC), assessed by echo-color Doppler, is an important marker of subclinical organ damage as well as expression of systemic vascular impairment. Recent data, on the other hand, have shown that also the aortic pulse wave velocity (PWVa), known measurement of arterial stiffness, both of early vascular damage index. Although depending in part by common pathogenic factors, IMTC and PWVa have no clinical significance quite comparable and are not infrequently conflicting with each other. It therefore seems interesting to identify which factors are associated with the divergent behavior of these parameters. They enrolled 263 patients with hypertension, aged between 30 and 70 years. All were subjected to measurement of PWV (by arteriograph) and eco-color-Doppler of the carotid district. The entire study population was divided into four groups: (I) IMTC <0.9 mm and PWVa <10 m / s; (II) IMTC> 0.9 mm and PWVa <10 m / s; (III) IMTC <0.9 mm and PWVa> 10 m / s; (IV) IMTC> 0.9 mm and PWVa> 10 m / s. The only variables associated with the discordant trend groups PWVa and IMTC were the weight (83.43 vs 73.21 kg; p = 0.021) and latrigliceridemia (146.53 vs 99.94 mg / dl; p = 0.028), which showed higher values in subjects the group II than those discordant group III. After analysis by logistic regression, both weight variables (p = 0.036; OR: 1.047; CI: 1003-1094), and triglycerides (p = 0.013; OR: 1.020; CI: 1004-1. 037) maintained the statistical significance despite correction for multiple confounders. The data of our study, however, still preliminary, seem to show that high levels of triglycerides, and weight can facilitate the identification of individuals with increased IMTC and normal or low PWV and vice versa.
Original languageItalian
Pages159-159
Number of pages1
Publication statusPublished - 2014

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