Background and purpose: Fatigue is a common symptom in amyotrophic lateralsclerosis (ALS). Although sleep disturbances are a candidate factor that may interferewith fatigue in patients with ALS, the role of sleep-related abnormalities in determiningfatigue in ALS is unknown.Objective: To evaluate the frequency and determinants of fatigue in a group of 91consecutive patients with ALS, with special attention to the relationship betweenfatigue and sleep problems.Methods: Measures included the Fatigue Severity Scale (FSS), Pittsburgh SleepQuality Index (PSQI), Epworth Sleepiness Scale (ESS), ALS Functional Rating Scale-Revised (ALSFRS-R), and Beck Depression Inventory (BDI).Results: The mean FSS score was 4.35 ± 1.1, and 48 patients with ALS (52.75%)reported clinical significant fatigue. FSS score correlated with ALSFRS-R score,forced vital capacity, ESS, BDI, and global PSQI score. Patients with fatigue weresignificantly more disabled and more frequently reported difficulties staying asleep andnocturnal complaints, such as nocturia and disturbing muscle cramps. After multivariateanalysis, patients disability and nocturnal complaints were significantlyassociated with fatigue.Conclusion: In this study, we demonstrated that fatigue, a troublesome and disablingsymptom in ALS, is associated with physical impairment and night-time complaints(such as nocturia and muscle cramps), suggesting that treating sleep problems mightbe useful in alleviating fatigue in these patients.
|Number of pages||4|
|Journal||EUROPEAN JOURNAL OF NEUROLOGY|
|Publication status||Published - 2012|
All Science Journal Classification (ASJC) codes
- Clinical Neurology