Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells

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Abstract

IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.
Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1028
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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