Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells

Monica Notarbartolo Di Villarosa; Paola Poma; Maria Meli; Lydia Giannitrapani; Luisa Dusonchet; Giuseppe Montalto; Natale D'Alessandro; Melchiorre Cervello; Natale D'Alessandro

Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells

Monica Notarbartolo Di Villarosa, Paola Poma, Maria Meli, Lydia Giannitrapani, Luisa Dusonchet, Giuseppe Montalto, Natale D'Alessandro, Melchiorre Cervello, Natale D'Alessandro

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche
Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.

Original language	English
Pages (from-to)	289-293
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1028
Publication status	Published - 2004

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells. / Notarbartolo Di Villarosa, Monica ; Poma, Paola ; Meli, Maria ; Giannitrapani, Lydia ; Dusonchet, Luisa ; Montalto, Giuseppe ; D'Alessandro, Natale; Cervello, Melchiorre; D'Alessandro, Natale.

In: Annals of the New York Academy of Sciences, Vol. 1028, 2004, p. 289-293.

Research output: Contribution to journal › Article › peer-review

Notarbartolo Di Villarosa, Monica ; Poma, Paola ; Meli, Maria ; Giannitrapani, Lydia ; Dusonchet, Luisa ; Montalto, Giuseppe ; D'Alessandro, Natale ; Cervello, Melchiorre ; D'Alessandro, Natale. / Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells. In: Annals of the New York Academy of Sciences. 2004 ; Vol. 1028. pp. 289-293.

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title = "Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells",

abstract = "IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.",

keywords = "IAPs, alternative splice variants, drug resistance, hepatocellular carcinoma, inhibitors of apoptosis proteins, IAPs, alternative splice variants, drug resistance, hepatocellular carcinoma, inhibitors of apoptosis proteins",

author = "{Notarbartolo Di Villarosa}, Monica and Paola Poma and Maria Meli and Lydia Giannitrapani and Luisa Dusonchet and Giuseppe Montalto and Natale D'Alessandro and Melchiorre Cervello and Natale D'Alessandro",

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T1 - Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells

AU - Notarbartolo Di Villarosa, Monica

AU - Poma, Paola

AU - Meli, Maria

AU - Giannitrapani, Lydia

AU - Dusonchet, Luisa

AU - Montalto, Giuseppe

AU - D'Alessandro, Natale

AU - Cervello, Melchiorre

AU - D'Alessandro, Natale

PY - 2004

Y1 - 2004

N2 - IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.

AB - IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.

KW - IAPs

KW - alternative splice variants

KW - drug resistance

KW - hepatocellular carcinoma

KW - inhibitors of apoptosis proteins

KW - IAPs

KW - alternative splice variants

KW - drug resistance

KW - hepatocellular carcinoma

KW - inhibitors of apoptosis proteins

UR - http://hdl.handle.net/10447/28790

M3 - Article

VL - 1028

SP - 289

EP - 293

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -