Exosomes as diagnostic and predictive biomarkers in lung cancer

Simona Taverna, Marzia Pucci, Antonio Russo, Pablo Reclusa Asiain, Silvia Calabuig, Simona Taverna, Antonio Russo, Marzia Pucci, Patrick Pauwels, Pablo Reclusa, Paolo Manca, Silvia Calabuig, Elena Durendez, Laure Sober, Christian Rolfo, María José Serrano, Christian Diego Rolfo

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)


The concept of exosomes has evolved from be considered garbage bags to the demonstration that exosomes could play very interesting roles and functions, from biomarkers detection to the potential of work as drug delivery systems. It has been widely proved that exosomes can contain key molecules important for the tumour development. The current review summarizes the latest investigations developed in the field of predictive exosomal biomarkers. The microRNAs (miRNAs) are the more known molecules due to their amount inside the exosomes and the sensitivity of the techniques available for their study. However, exosomal proteins, RNA and DNA are becoming an interesting and more feasible field of study due to the improvement in the techniques available for their analysis. In the future years, it is hoped that exosomes will become an established member of the liquid biopsies in the clinical practice due to their diagnostic and prognostic properties.
Original languageEnglish
Pages (from-to)S1373-S1382
Number of pages10
JournalJournal of Thoracic Disease
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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