Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells

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Abstract

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the Bcr–Abl oncoproteinwith constitutive tyrosine kinase activity. Exosomes are nanovesicles released by cancer cells thatare involved in cell-to-cell communication thus potentially affecting cancer progression. It is well knownthat bone marrow stromal microenvironment contributes to disease progression through the establishmentof a bi-directional crosstalk with cancer cells. Our hypothesis is that exosomes could have a functionalrole in this crosstalk. Interleukin-8 (IL 8) is a proinflammatory chemokine that activates multiplesignalling pathways downstream of two receptors (CXCR1 and CXCR2). We demonstrated that exosomesreleased from CML cells stimulate bone marrow stromal cells to produce IL 8 that, in turn, is able to modulateboth in vitro and in vivo the leukemia cell malignant phenotype.
Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalCancer Letters
Volume348
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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